Search results for "Endocrine disease"

showing 6 items of 6 documents

Abnormal pentagastrin response in a patient with pseudohypoparathyroidism

2002

The case of a 25 year old female patient with pseudohypoparathyroidism type I (PHP) and hypercalcitoninaemia is reported. She was referred to our clinic because of recurrent hypocalcaemia associated with paraesthesias and muscle cramps. She had no signs of Albright hereditary osteodystrophy (AHO), a normal mental status and no family history of hypocalcaemia or any other endocrine disease. Considering the laboratory results with hypocalcaemia, hyperphosphataemia, normal vitamin D and normal creatinine with an extraordinary elevated PTH we diagnosed pseudohypoparathyroidism type I. She had delayed pubertal development with menarche in the age of 20 and hypothyroidism with an atrophic thyroid…

AdultCalcitoninmusculoskeletal diseasesmedicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and MetabolismGastroenterologyPhosphatesEndocrinologyHypothyroidismInternal medicineInternal MedicinemedicineHumansHypocalcaemiaFamily historyPseudohypoparathyroidismPuberty DelayedEndocrine diseaseHypocalcemiabusiness.industryThyroidGeneral MedicineAlkaline Phosphatasemedicine.diseasePentagastrinmedicine.anatomical_structureEndocrinologyCalcitoninPseudohypoparathyroidismCalciumFemalePentagastrinmedicine.symptombusinessMuscle crampmedicine.drugExperimental and Clinical Endocrinology & Diabetes
researchProduct

Anti-Inflammatory Action of Heterogeneous Nuclear Ribonucleoprotein A2/B1 in Patients with Autoimmune Endocrine Disorders

2019

Our previous studies documented that human fibroblast-limbal stem cells (f-LSCs) possess immunosuppressive capabilities, playing a role in regulating T-cell activity. This study highlights the molecular activities by which human f-LSCs can attenuate the inflammatory responses of self-reactive peripheral blood mononuclear cells (PBMCs) collected from patients with autoimmune endocrine diseases (AEDs). Anti-CD3 activated PBMCs from twenty healthy donors and fifty-two patients with AEDs were cocultured on f-LSC monolayer. 2D-DIGE proteomic experiments, mass spectrometry sequencing and functional in vitro assays were assessed in cocultured PBMCs. We identified the downmodulation of several huma…

Gene isoformInflammationfibroblast-limbal stem cells Autoimmune Endocrine DiseaseNF-ĸB interaction.Peripheral blood mononuclear cellArticleSettore MED/13 - EndocrinologiaAutoimmune Endocrine Diseases03 medical and health sciencesNF-ĸB interaction0302 clinical medicinemedicineGene silencingIL-2 receptorSettore BIO/06 - Anatomia Comparata E CitologiaHeterogeneous Nuclear Ribonucleoprotein A2/B1hnRNP A2/B1030304 developmental biology0303 health sciencesSettore MED/30 - Malattie Apparato Visivobusiness.industryautoimmunityGeneral Medicinefibroblast-limbal stem cellsSettore BIO/18 - Genetica030220 oncology & carcinogenesisCancer researchfibroblast-limbal stem cells Autoimmune Endocrine Diseasesmedicine.symptomStem cellbusinessCD8immunotoleranceJournal of Clinical Medicine
researchProduct

Neonatal screening for congenital hypothyroidism in an Italian Centre: a 5-years real-life retrospective study

2021

Abstract Introduction Congenital hypothyroidism is an endocrine disease with a significant incidence in the general population (1:2000–1:3000 newborns in Italy) and a different geographical distribution, partially explained by endemic iodine deficiency, genetic traits and autoimmune thyroid diseases. Objectives Aims of this study are: to evaluate the incidence of positive neonatal blood spot screening for CH in western Sicily, identified by the screening centre of the Children Hospital “G. Di Cristina”, ARNAS, Palermo; to evaluate the impact of a lower TSH cutoff in the neonatal blood spot screening for CH. Materials and methods The TSH threshold of the neonatal screening was established as…

MalePediatricsmedicine.medical_specialtyendocrine systemendocrine system diseasesPopulationIodine deficiencyNeonatal screening TSH Twins Congenital Hypothyroidism Female Humans Incidence Infant Newborn Male Retrospective Studies Risk Factors SicilyTwins030209 endocrinology & metabolismPediatricsRJ1-57003 medical and health sciences0302 clinical medicineNeonatal ScreeningRisk Factors030225 pediatricsMedicineHumanseducationSicilyWhole bloodRetrospective Studieseducation.field_of_studyEndocrine diseasebusiness.industryTSHIncidence (epidemiology)ResearchIncidenceThyroidInfant NewbornRetrospective cohort studymedicine.diseaseIodine deficiencyCongenital hypothyroidismCongenital hypothyroidismmedicine.anatomical_structureFemalebusinessIodine deficiencyItalian Journal of Pediatrics
researchProduct

Upper and Lower Limb Strength and Body Posture in Children with Congenital Hypothyroidism: An Observational Case-Control Study

2020

Background: Congenital hypothyroidism (CH) is an endocrine disease with a precocious significant impairment of growth and neuromotor development. Thyroid hormones are essential for central nervous system development, maturation, and myelination. Furthermore, thyroid hormone deficiency affects the function of several systems, including the musculoskeletal system. The disease has a significant incidence in the general population (1:3000–1:2000 newborns in Italy). The aim of the present study was to evaluate any differences in upper and lower limb strength, body sway, and plantar loading distribution in children with CH compared to healthy children. Methods: In this study, the case group was c…

Malemedicine.medical_specialtyAdolescentHealth Toxicology and MutagenesisPopulationPosturelcsh:Medicine030209 endocrinology & metabolismIsometric exerciseArticle03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansbody swayeducationChildMuscle SkeletalPostural Balancecongenital hypothyroidism; muscle strength; handgrip test; Sargent test; body sway; plantar pressure; postureUnivariate analysiseducation.field_of_studyEndocrine diseaseSettore M-EDF/02 - Metodi E Didattiche Delle Attivita' SportiveHand Strengthbusiness.industryThyroidlcsh:RPublic Health Environmental and Occupational HealthCase-control studycongenital hypothyroidismmedicine.diseaseSargent testCongenital hypothyroidismmedicine.anatomical_structureItalyBody sway Congenital hypothyroidism Handgrip test Muscle strength Plantar pressure PostureCase-Control StudiesCardiologymuscle strengthplantar pressureFemalehandgrip testbusinessSettore M-EDF/01 - Metodi E Didattiche Delle Attivita' Motorie030217 neurology & neurosurgeryFoot (unit)International Journal of Environmental Research and Public Health
researchProduct

Adolescents with Chronic Endocrine Diseases:a Multidisciplinary Approach: the Experience of the Paediatric Clinic of Palermo

2014

Settore MED/38 - Pediatria Generale E SpecialisticaChronic Endocrine Diseases Multidisciplinary Approach
researchProduct

Impact of Endocrine Disorders on IVF Outcomes: Results from a Large, Single-Centre, Prospective Study

2022

Abstract Endocrine disorders negatively influence the ovarian function, and increasing incidence of endocrine diseases with age may have further negative effects on pregnancy rate. Prospective cohort study of 231 consecutively enrolled patients underwent IVF treatment. In patients with known endocrine disorders, the laboratory parameters were corrected before IVF treatment. One hundred sixty one patients (69.7%) had at least one known and treated endocrine disorder (study group), and 70 patients were endocrine negative (control group). Endocrine disorders diagnosed were thyroid disorders (32.5%), diminished ovarian reserve (23.8%), insulin resistance (22.5%), PCOS (15.2%), hyperprolactinaem…

Thyroid diseasesAssisted reproductionIn vitro fertilizationObstetrics and GynecologySettore MED/40 - Ginecologia E OstetriciaEndocrine diseases
researchProduct